Structural basis of γ-secretase inhibition and modulation by small molecule drugsCryo-EM structures of human γ-secretase bound to three inhibitors and a modulator reveal the differential modes of recognition, paving the way for development of substrate-selective γ-secretase inhibitors.Cryo-EM structures of human γ-secretase bound to three inhibitors and a modulator reveal the differential modes of recognition, paving the way for development of substrate-selective γ-secretase inhibitors.Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei, Yigong Shihttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931621-4%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 29, 2020

Powered by WPeMatico