Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cellsWhen transplanting engineered hematopoietic stem/progenitor cells, mobilizing the existing HSPCs out of the bone marrow can allow for the engraftment of new cells without the need to treat study animals with chemotherapy. This presents an opportunity to overcome the toxicity challenge that chemotherapy presents for HSPC transplantation […]
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