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Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacyTransfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract exhaustion and fight tumors more effectively.Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, […]

A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytesThe biosynthetic pathways in plants that yield important and clinically relevant toxins are complicated and difficult to elucidate. Through combined metabolomics, the biosynthetic pathways of a structurally and functionally diverse set of toxins are discovered, suggesting a model for the production of defense metabolites […]

Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organRUSH3D, with the integration of multiple computational imaging methods based on a scanning light-field framework, facilitates long-term, high-speed, centimeter-wide mesoscale 3D imaging at single-cell resolution in a compact system for broad practical applications in understanding large-scale intercellular dynamics at the mammalian organ level. We have […]

Neoself-antigens are the primary target for autoreactive T cells in human lupusThe discrimination of self- and neoself-antigens by T cells plays a crucial role in the activation of autoreactive T cells, leading to the development of autoimmunity. The reactivation of the Epstein-Barr virus is a possible factor that causes MHC class II molecules to present neoself-antigens by decreasing […]

Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor functionRING-Bait technology hijacks the process of templated aggregation to recruit ubiquitination machinery and selectively degrade pathogenic tau assemblies without generating a specific binder, thereby reducing tau pathology and improving motor function in vivo.RING-Bait technology hijacks the process of templated aggregation to recruit ubiquitination machinery and […]

How are telcos embracing AI in the RAN?According to Blue Plant’s VP, telcos will lean into AI in the RAN much more ‘aggressively’ in the 6G era Even as 5G has yet to deliver on many of its promises, the balance is shifting; more and more conversations are beginning to favor the topic of 6G […]

China unveils plan to boost mobile IoT sectorChina anticipates supporting 3.6 billion mobile IoT connections by 2027 China’s Ministry of Industry and Information Technology has introduced a plan to advance the development of the mobile Internet of Things (IoT) sector in the country, Chinese press reported. This initiative is aimed at enhancing the sector’s supply […]