State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides

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State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptidesCell-permeable Gαs inhibitors regulate G protein signal transduction with high nucleotide-binding-state selectivity and class specificity.Cell-permeable Gαs inhibitors regulate G protein signal transduction with high nucleotide-binding-state selectivity and class specificity.Shizhong A. Dai, Qi Hu, Rong Gao, Emily E. Blythe, Kouki K. Touhara, Hayden Peacock, Ziyang Zhang, Mark von […]

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Fortinet brings AIOps smarts to 5G/LTE gateway management

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Fortinet brings AIOps smarts to 5G/LTE gateway management“AI and ML have been a core part of our offering for a decade plus,” said Fortinet’s VP of products Cybersecurity software maker Fortinet announced Tuesday enhanced Artificial Intelligences Operations (AIOps) capabilities across its network software portfolio, including its Software-Defined Wide Area Networking (SD-WAN), wired and wireless Local Area Network […]

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‘War, religion and politics’: Real-world conflicts play out in cyberattacks, Netscout report finds

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‘War, religion and politics’: Real-world conflicts play out in cyberattacks, Netscout report findsNew Netscout report says botnets are “more potent than ever before” Geopolitical tensions involving Russia and Ukraine are being reflected in cyberattacks, while botnets “continue to evolve at a frightening pace,” according to a new security report from Netscout. Netscout, which draw the […]

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Orange Belgium deploys 5G Standalone core network

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Orange Belgium deploys 5G Standalone core networkOrange Belgium is deploying its 5G SA network in partnership with Ericsson, Nokia and Oracle Orange Belgium said it is deploying a 5G Standalone core network on a cloud-native architecture together with partners Ericsson, Nokia and Oracle. Orange Belgium said that it is working with Ericsson for the packet […]

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Ng-voice, Casa Systems team up for cloud-native IMS for 4G, 5G

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Ng-voice, Casa Systems team up for cloud-native IMS for 4G, 5GThe partnership yields “a very competitive joint offering” for private 4G and 5G, according to ng-voice’s CEO Telecom software maker ng-voice has announced a new partnership with telco infrastructure software maker Casa Systems which ng-voice says will yield fully cloud-native 4G and 5G solutions for […]

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Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses

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Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responsesFor COVID-19 mRNA vaccines, immunization with a booster dose elicits robust antibody and B-cell responses that are further increased if a breakthrough infection occurs after vaccination. In contrast, when infection occurs prior to booster vaccination, antibody and B-cell […]

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Quorum-sensing- and type VI secretion-mediated spatiotemporal cell death drives genetic diversity in Vibrio cholerae

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Quorum-sensing- and type VI secretion-mediated spatiotemporal cell death drives genetic diversity in Vibrio choleraeType VI secretion system-mediated cell death in Vibrio cholerae colonies occurs in two space- and time-differentiated phases that cause death along the colony rim and interior, respectively. Cell death at the colony rim is a consequence of kin-killing and is proposed to […]

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ER stress transforms random olfactory receptor choice into axon targeting precision

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ER stress transforms random olfactory receptor choice into axon targeting precisionER stress levels in olfactory sensory neurons are influenced by olfactory receptor protein sequences, which lead to distinct patterns of axon guidance gene expression and specific axon targeting to glomeruli.ER stress levels in olfactory sensory neurons are influenced by olfactory receptor protein sequences, which lead […]

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