Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editingCRISPRoff programs heritable epigenetic memory and is able to heritably silence most genes, including genes without CpG islands. This heritable silencing is highly specific and persists through differentiation of iPSCs into neurons.CRISPRoff programs heritable epigenetic memory and is able to heritably silence most genes, including genes without CpG […]
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