Our News

Sleep is required to consolidate odor memory and remodel olfactory synapsesA sleep-like state is required for memory consolidation and synaptic remodeling, even in organisms with relatively small nervous systems, such as C. elegans, in which it is possible to examine how sleep affects individual neurons and their connections.A sleep-like state is required for memory consolidation and […]

Distinct longevity mechanisms across and within species and their association with agingThe analysis of multi-tissue gene expression signatures associated with longevity across mammalian species and their interaction with biomarkers of aging and signatures of lifespan-extending interventions reveals universal and distinct strategies of lifespan regulation within and across species and provides tools for the discovery of […]

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticitySelective CDK2 inhibition initially blocks substrate phosphorylation. However, because of a potent positive feedback loop and reinforcement by CDK4/6 activity, cells can rapidly overcome CDK2 inhibition to complete the cell cycle.Selective CDK2 inhibition initially blocks substrate phosphorylation. However, because of a potent positive feedback loop and reinforcement […]

Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormonesMBOAT1 and MBOAT2 are sex hormone-dependent ferroptosis regulators with therapeutic implications for ER+ breast cancer and AR+ prostate cancer, respectively.MBOAT1 and MBOAT2 are sex hormone-dependent ferroptosis regulators with therapeutic implications for ER+ breast cancer and AR+ prostate cancer, respectively.Deguang Liang, Yan Feng, Fereshteh Zandkarimi, Hua […]

NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPsNLRP12 is an immune sensor that activates cell death and inflammation when it senses heme and pathogen-associated molecular danger signals indicative of hemolytic diseases.NLRP12 is an immune sensor that activates cell death and inflammation when it senses heme and pathogen-associated molecular danger signals indicative of […]

Generating parallel representations of position and identity in the olfactory systemAn active contrast circuit effectively allows flies to “see” each other using smell.An active contrast circuit effectively allows flies to “see” each other using smell.István Taisz, Erika Donà, Daniel Münch, Shanice N. Bailey, Billy J. Morris, Kimberly I. Meechan, Katie M. Stevens, Irene Varela-Martínez, Marina […]

The enteric nervous system relays psychological stress to intestinal inflammationPsychological stress and chronically elevated glucocorticoid levels induce inflammatory enteric glia and transcriptional immaturity in enteric neurons, leading to dysmotility and predisposing the intestine to monocyte-mediated inflammation.Psychological stress and chronically elevated glucocorticoid levels induce inflammatory enteric glia and transcriptional immaturity in enteric neurons, leading to dysmotility […]

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphateAnalyses of Spns2 illuminate a distinct transport mechanism for the crucial signaling molecule sphingosine-1-phosphate (S1P) and the basis of pharmacological inhibition of the transporter.Analyses of Spns2 illuminate a distinct transport mechanism for the crucial signaling molecule sphingosine-1-phosphate (S1P) and the basis of pharmacological inhibition of the transporter.Hongwen […]

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infectionBeyond liver-derived complement component C5, locally produced C5 is a critical mediator of antifungal defense in infected tissues, and this finding explains the susceptibility of patients to systemic Candida infection after C5 inhibition therapy.Beyond liver-derived complement component C5, locally produced C5 is a critical mediator of antifungal […]

Site-specific R-loops induce CGG repeat contraction and fragile X gene reactivationSite-specific R-loop formation leads to the contraction of expanded CGG repeats associated with fragile X syndrome and restores expression of the silenced FMRP protein.Site-specific R-loop formation leads to the contraction of expanded CGG repeats associated with fragile X syndrome and restores expression of the silenced […]