KCNE1 is an auxiliary subunit of two distinct ion channel superfamiliesKCNE1, a β-subunit of the cardiac KCNQ1 channel belonging to the voltage-dependent channel superfamily, serves also as an auxiliary subunit of the anoctamin superfamily member TMEM16A, a calcium-activated chloride channel. By interacting with TMEM16A, KCNE1 induces a voltage-dependent current in the absence of intracellular calcium elevation dynamically regulated by angiotensin II in native tissue.KCNE1, a β-subunit of the cardiac KCNQ1 channel belonging to the voltage-dependent channel superfamily, serves also as an auxiliary subunit of the anoctamin superfamily member TMEM16A, a calcium-activated chloride channel. By interacting with TMEM16A, KCNE1 induces a voltage-dependent current in the absence of intracellular calcium elevation dynamically regulated by angiotensin II in native tissue.Pablo Ávalos Prado, Stephanie Häfner, Yannick Comoglio, Brigitte Wdziekonski, Christophe Duranton, Bernard Attali, Jacques Barhanin, Guillaume Sandozhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931619-6%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 29, 2020

Powered by WPeMatico