Cytomegalovirus subverts macrophage identity

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Cytomegalovirus subverts macrophage identityCo-evolution of CMVs and their hosts has led to exploitation of the first line of defense and conserved signaling pathways. Upon infection, macrophages are targeted primarily by MCMV and reprogrammed via activation of Wnt and TGF-β. This cell state serves viral replication and dissemination at the expense of cell-intrinsic traits.Co-evolution of CMVs and their hosts has led to exploitation of the first line of defense and conserved signaling pathways. Upon infection, macrophages are targeted primarily by MCMV and reprogrammed via activation of Wnt and TGF-β. This cell state serves viral replication and dissemination at the expense of cell-intrinsic traits.Sebastian Baasch, Piero Giansanti, Julia Kolter, André Riedl, Aaron James Forde, Solveig Runge, Simon Zenke, Roland Elling, Anne Halenius, Simone Brabletz, Hartmut Hengel, Bernhard Kuster, Thomas Brabletz, Luka Cicin-Sain, Ramon Arens, Andreas Vlachos, Jan Christopher Rohr, Marc Philippe Stemmler, Manfred Kopf, Zsolt Ruzsics, Philipp Hennekehttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2900626-7%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJune 11, 2021

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