Chromatin context-dependent regulation and epigenetic manipulation of prime editingPrime editing exhibits strong, chromatin-related position effects and is promoted by active transcriptional elongation. Leveraging these features via epigenetic conditioning of a locus modulates prime editing efficiency.Prime editing exhibits strong, chromatin-related position effects and is promoted by active transcriptional elongation. Leveraging these features via epigenetic conditioning of a locus modulates prime editing efficiency.Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy A. McDiarmid, Riza M. Daza, Haedong Kim, Jean-Benoît Lalanne, Jenny F. Nathans, David S. Lee, Jay Shendurehttps://www.cell.com/cell/fulltext/S0092-8674(24)00311-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 12, 2024

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