Baricitinib treatment resolves lower airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

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Baricitinib treatment resolves lower airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaquesUsing a rhesus macaque infection model it is shown that baricitinib treatment started early after infection effectively resolves inflammatory signatures in airway macrophages, with decreased lung pathology and neutrophil infiltration.Using a rhesus macaque infection model it is shown that baricitinib treatment started early after infection effectively resolves inflammatory signatures in airway macrophages, with decreased lung pathology and neutrophil infiltration.Timothy N. Hoang, Maria Pino, Arun K. Boddapati, Elise G. Viox, Carly E. Starke, Amit A. Upadhyay, Sanjeev Gumber, Michael Nekorchuk, Kathleen Busman-Sahay, Zachary Strongin, Justin L. Harper, Gregory K. Tharp, Kathryn L. Pellegrini, Shannon Kirejczyk, Keivan Zandi, Sijia Tao, Tristan R. Horton, Elizabeth N. Beagle, Ernestine A. Mahar, Michelle YH. Lee, Joyce Cohen, Sherrie M. Jean, Jennifer S. Wood, Fawn Connor-Stroud, Rachelle L. Stammen, Olivia M. Delmas, Shelly Wang, Kimberly A. Cooney, Michael N. Sayegh, Lanfang Wang, Peter D. Filev, Daniela Weiskopf, Guido Silvestri, Jesse Waggoner, Anne Piantadosi, Sudhir P. Kasturi, Hilmi Al-Shakhshir, Susan P. Ribeiro, Rafick P. Sekaly, Rebecca D. Levit, Jacob D. Estes, Thomas H. Vanderford, Raymond F. Schinazi, Steven E. Bosinger, Mirko Paiardinihttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931466-5%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 10, 2020

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