Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variants

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Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variantsThe SARS-CoV-2 BA.2.86 variant is less resistant to neutralization by bivalent vaccine-induced antibodies compared to FLip and other XBB variants but more resistant to mAb S309. BA.2.86 shows higher fusogenicity and infectivity in CaLu-3 cells compared to that in 293T-ACE2 cells.The SARS-CoV-2 BA.2.86 variant is less resistant to neutralization by bivalent vaccine-induced antibodies compared to FLip and other XBB variants but more resistant to mAb S309. BA.2.86 shows higher fusogenicity and infectivity in CaLu-3 cells compared to that in 293T-ACE2 cells.Panke Qu, Kai Xu, Julia N. Faraone, Negin Goodarzi, Yi-Min Zheng, Claire Carlin, Joseph S. Bednash, Jeffrey C. Horowitz, Rama K. Mallampalli, Linda J. Saif, Eugene M. Oltz, Daniel Jones, Richard J. Gumina, Shan-Lu Liuhttps://www.cell.com/cell/fulltext/S0092-8674(23)01400-9?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 9, 2024

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