Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathwayThe microbial bile acid 3-succinylated cholic acid is biosynthesized by BAS-suc, an enzyme annotated as β-lactamase in Bacteroides uniformis, and it alleviates MASH progression by enriching the abundance of the beneficial gut bacterium Akkermansia muciniphila.The microbial bile acid 3-succinylated cholic acid is biosynthesized by BAS-suc, an enzyme annotated as β-lactamase in Bacteroides uniformis, and it alleviates MASH progression by enriching the abundance of the beneficial gut bacterium Akkermansia muciniphila.Qixing Nie, Xi Luo, Kai Wang, Yong Ding, Shumi Jia, Qixiang Zhao, Meng Li, Jinxin Zhang, Yingying Zhuo, Jun Lin, Chenghao Guo, Zhiwei Zhang, Huiying Liu, Guangyi Zeng, Jie You, Lulu Sun, Hua Lu, Ming Ma, Yanxing Jia, Ming-Hua Zheng, Yanli Pang, Jie Qiao, Changtao Jianghttps://www.cell.com/cell/fulltext/S0092-8674(24)00350-7?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 23, 2024

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