Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcriptionDeep mutational scanning reveals that conserved proline codons at the 3′ end of the hepatitis B virus polymerase open reading frame stall ribosomes. As a result, the ribosome physically tethers the nascent polymerase to its encoding RNA, which enforces cis-preferential genome RNA packaging and reverse transcription.Deep mutational scanning reveals that conserved proline codons at the 3′ end of the hepatitis B virus polymerase open reading frame stall ribosomes. As a result, the ribosome physically tethers the nascent polymerase to its encoding RNA, which enforces cis-preferential genome RNA packaging and reverse transcription.Yingpu Yu, Maximilian A. Kass, Mengyin Zhang, Noor Youssef, Catherine A. Freije, Kelly P. Brock, Lauren C. Aguado, Leon L. Seifert, Sanjana Venkittu, Xupeng Hong, Amir Shlomai, Ype P. de Jong, Debora S. Marks, Charles M. Rice, William M. Schneiderhttps://www.cell.com/cell/fulltext/S0092-8674(24)00403-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 9, 2024

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