Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacyEfficacy of CAR T cell therapy and immune checkpoint blockade in cancer can be improved by adjusting the time of treatment during the day due to rhythmic infiltration and function of T cells regulated by the circadian clock in T cells and endothelial cells in the tumor microenvironment.Efficacy of CAR T cell therapy and immune checkpoint blockade in cancer can be improved by adjusting the time of treatment during the day due to rhythmic infiltration and function of T cells regulated by the circadian clock in T cells and endothelial cells in the tumor microenvironment.Chen Wang, Qun Zeng, Zeynep Melis Gül, Sisi Wang, Robert Pick, Phil Cheng, Ruben Bill, Yan Wu, Stefan Naulaerts, Coline Barnoud, Pei-Chun Hsueh, Sofie Hedlund Moller, Mara Cenerenti, Mengzhu Sun, Ziyang Su, Stéphane Jemelin, Volodymyr Petrenko, Charna Dibner, Stéphanie Hugues, Camilla Jandus, Zhongwu Li, Olivier Michielin, Ping-Chih Ho, Abhishek D. Garg, Federico Simonetta, Mikaël J. Pittet, Christoph Scheiermannhttps://www.cell.com/cell/fulltext/S0092-8674(24)00410-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 9, 2024

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