Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesisZong et al. identified the tumor-derived L-lactate as a natural suppressor of p53 and screened out AARS1 as an intracellular L-lactate sensor and lactyl-transferase that mediates global lysine lactylation and also targets p53. Lactylation of p53 at specific lysine residues in the DNA-binding domain attenuates their DNA binding and liquid-liquid phase separation (LLPS) thereby reducing p53 tumor-suppressive roles both in vitro and in vivo.Zong et al. identified the tumor-derived L-lactate as a natural suppressor of p53 and screened out AARS1 as an intracellular L-lactate sensor and lactyl-transferase that mediates global lysine lactylation and also targets p53. Lactylation of p53 at specific lysine residues in the DNA-binding domain attenuates their DNA binding and liquid-liquid phase separation (LLPS) thereby reducing p53 tumor-suppressive roles both in vitro and in vivo.Zhi Zong, Feng Xie, Shuai Wang, Xiaojin Wu, Zhenyu Zhang, Bing Yang, Fangfang Zhouhttps://www.cell.com/cell/fulltext/S0092-8674(24)00397-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 23, 2024

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