Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologiesA family of ENGases secreted by corynebacterial species strictly targeting the Asn297-linked glycan on human IgG antibodies was discovered. The prototypical family member, CU43, demonstrated remarkable efficacy in treating pathologies that rely on Fc γ receptor (FcγR)-mediated effector functions, including T and B lymphocyte depletion, autoimmune hemolytic anemia, and antibody-dependent enhancement of dengue disease activity.A family of ENGases secreted by corynebacterial species strictly targeting the Asn297-linked glycan on human IgG antibodies was discovered. The prototypical family member, CU43, demonstrated remarkable efficacy in treating pathologies that rely on Fc γ receptor (FcγR)-mediated effector functions, including T and B lymphocyte depletion, autoimmune hemolytic anemia, and antibody-dependent enhancement of dengue disease activity.Diego E. Sastre, Stylianos Bournazos, Jonathan Du, E. Josephine Boder, Julia E. Edgar, Tala Azzam, Nazneen Sultana, Maros Huliciak, Maria Flowers, Lea Yoza, Ting Xu, Tatiana A. Chernova, Jeffrey V. Ravetch, Eric J. Sundberghttps://www.cell.com/cell/fulltext/S0092-8674(24)01135-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 22, 2024

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