De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responsesLiu et al. uncover that the rapid assembly of nuclear stress bodies (nSBs) upon sensing stresses leads to local gene rearrangement with enhanced transcription. Importantly, the nSB assembly-driven NFIL3 upregulation restrains acute inflammatory responses by suppressing expression of key inflammatory cytokines, a process that positively correlates with septic patient survival.Liu et al. uncover that the rapid assembly of nuclear stress bodies (nSBs) upon sensing stresses leads to local gene rearrangement with enhanced transcription. Importantly, the nSB assembly-driven NFIL3 upregulation restrains acute inflammatory responses by suppressing expression of key inflammatory cytokines, a process that positively correlates with septic patient survival.Xiao-Qi Liu, Pan Li, Bao-Qing Gao, Heng-Le Zhu, Liang-Zhong Yang, Yang Wang, Yu-Yao Zhang, Hao Wu, Yu-Hang Pan, Lin Shan, Hongtao Yu, Li Yang, Ling-Ling Chenhttps://www.cell.com/cell/fulltext/S0092-8674(25)00514-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 28, 2025

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