Comprehensive maturity of nuclear pore complexes regulates zygotic genome activationExperiments in zebrafish indicate that nuclear pore complex (NPC) maturation serves as a molecular timer of zygote genome activation, a key part of the oocyte-to-embryo transition during vertebrate development. Increased size and complexity of NPCs leads to increased nuclear transport of maternal transcription factors, allowing transcription factors to reach thresholds that initiate zygotic genome activation.Experiments in zebrafish indicate that nuclear pore complex (NPC) maturation serves as a molecular timer of zygote genome activation, a key part of the oocyte-to-embryo transition during vertebrate development. Increased size and complexity of NPCs leads to increased nuclear transport of maternal transcription factors, allowing transcription factors to reach thresholds that initiate zygotic genome activation.Weimin Shen, Bo Gong, Cencan Xing, Lin Zhang, Jiawei Sun, Yuling Chen, Changmei Yang, Lu Yan, Luxi Chen, Likun Yao, Guangyuan Li, Haiteng Deng, Xiaotong Wu, Anming Menghttps://www.cell.com/cell/fulltext/S0092-8674(22)01423-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 9, 2022

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