Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channelsCo-administration of sofosbuvir and amiodarone can lead to fatal heartbeat slowing, yet the underlying mechanism has not been clear. Analyzing six cryo-EM structures of Cav1.1 and Cav1.3 in the presence of these drugs reveals their direct interaction within the channels and explains this clinical observation.Co-administration of sofosbuvir and amiodarone can lead to fatal heartbeat slowing, yet the underlying mechanism has not been clear. Analyzing six cryo-EM structures of Cav1.1 and Cav1.3 in the presence of these drugs reveals their direct interaction within the channels and explains this clinical observation.Xia Yao, Shuai Gao, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yanhttps://www.cell.com/cell/fulltext/S0092-8674(22)01370-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 23, 2022

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