Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissuesPatho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA, microRNA, tRNA, splicing isoform, etc.) all at once in clinical formalin-fixed paraffin-embedded tissue with high sensitivity and coverage. It further allows for genome-wide mapping of single-nucleotide RNA variants to distinguish subclones and dissect spatiotemporal tumorigenesis at the cellular level.Patho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA, microRNA, tRNA, splicing isoform, etc.) all at once in clinical formalin-fixed paraffin-embedded tissue with high sensitivity and coverage. It further allows for genome-wide mapping of single-nucleotide RNA variants to distinguish subclones and dissect spatiotemporal tumorigenesis at the cellular level.Zhiliang Bai, Dingyao Zhang, Yan Gao, Bo Tao, Daiwei Zhang, Shuozhen Bao, Archibald Enninful, Yadong Wang, Haikuo Li, Graham Su, Xiaolong Tian, Ningning Zhang, Yang Xiao, Yang Liu, Mark Gerstein, Mingyao Li, Yi Xing, Jun Lu, Mina L. Xu, Rong Fanhttps://www.cell.com/cell/fulltext/S0092-8674(24)01019-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 1, 2024

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