Rewriting regulatory DNA to dissect and reprogram gene expressionMartyn and Montgomery et al. present Variant-EFFECTS, a high-throughput technology developed to precisely measure the effects of CRISPR-mediated edits on gene expression. Variant-EFFECTS is reproducible, is highly sensitive, and reveals the cell-type-specific function, context dependence, and programmability of regulatory DNA sequences in the human genome.Martyn and Montgomery et al. present Variant-EFFECTS, a high-throughput technology developed to precisely measure the effects of CRISPR-mediated edits on gene expression. Variant-EFFECTS is reproducible, is highly sensitive, and reveals the cell-type-specific function, context dependence, and programmability of regulatory DNA sequences in the human genome.Gabriella E. Martyn, Michael T. Montgomery, Hank Jones, Katherine Guo, Benjamin R. Doughty, Johannes Linder, Deepa Bisht, Fan Xia, Xiangmeng S. Cai, Ziwei Chen, Kelly Cochran, Kathryn A. Lawrence, Glen Munson, Anusri Pampari, Charles P. Fulco, Nidhi Sahni, David R. Kelley, Eric S. Lander, Anshul Kundaje, Jesse M. Engreitzhttps://www.cell.com/cell/fulltext/S0092-8674(25)00352-6?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 17, 2025

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