Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticitySelective CDK2 inhibition initially blocks substrate phosphorylation. However, because of a potent positive feedback loop and reinforcement by CDK4/6 activity, cells can rapidly overcome CDK2 inhibition to complete the cell cycle.Selective CDK2 inhibition initially blocks substrate phosphorylation. However, because of a potent positive feedback loop and reinforcement by CDK4/6 activity, cells can rapidly overcome CDK2 inhibition to complete the cell cycle.Mansi Arora, Justin Moser, Timothy E. Hoffman, Lotte P. Watts, Mingwei Min, Monica Musteanu, Yao Rong, C. Ryland Ill, Varuna Nangia, Jordan Schneider, Manuel Sanclemente, John Lapek, Lisa Nguyen, Sherry Niessen, Stephen Dann, Todd VanArsdale, Mariano Barbacid, Nichol Miller, Sabrina L. Spencerhttps://www.cell.com/cell/fulltext/S0092-8674(23)00532-9?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJune 2, 2023

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