Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronavirusesThe family of coronaviruses known as merbecoviruses has generally been thought to use the host cell protein DPP4 for entry, but this study shows that the merbecovirus HKU5 can enter host cells of the bat Pipistrellus abramus and other non-bat mammalian hosts through use of ACE2. Several merbecovirus clades independently evolved the ability to use ACE2 through distinct binding modes, and structure-function insights suggest ways that coronavirus infection can be inhibited.The family of coronaviruses known as merbecoviruses has generally been thought to use the host cell protein DPP4 for entry, but this study shows that the merbecovirus HKU5 can enter host cells of the bat Pipistrellus abramus and other non-bat mammalian hosts through use of ACE2. Several merbecovirus clades independently evolved the ability to use ACE2 through distinct binding modes, and structure-function insights suggest ways that coronavirus infection can be inhibited.Young-Jun Park, Chen Liu, Jimin Lee, Jack T. Brown, Cheng-Bao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K. Zepeda, Cameron Stewart, Amin Addetia, Caroline J. Craig, M. Alejandra Tortorici, Abeer N. Alshukairi, Tyler N. Starr, Huan Yan, David Veeslerhttps://www.cell.com/cell/fulltext/S0092-8674(24)01475-2?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignFebruary 8, 2025

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