Intestinal transgene delivery with native E. coli chassis allows persistent physiological changesNative E. coli strains isolated from mouse stool are genetically engineered for long-term engraftment in the conventional mouse gut and enable long-term systemic effects on the host, such as improvements in insulin sensitivity in mouse models of type 2 diabetes.Native E. coli strains isolated from mouse stool are genetically engineered for long-term engraftment in the conventional mouse gut and enable long-term systemic effects on the host, such as improvements in insulin sensitivity in mouse models of type 2 diabetes.Baylee J. Russell, Steven D. Brown, Nicole Siguenza, Irene Mai, Anand R. Saran, Amulya Lingaraju, Erica S. Maissy, Ana C. Dantas Machado, Antonio F.M. Pinto, Concepcion Sanchez, Leigh-Ana Rossitto, Yukiko Miyamoto, R. Alexander Richter, Samuel B. Ho, Lars Eckmann, Jeff Hasty, David J. Gonzalez, Alan Saghatelian, Rob Knight, Amir Zarrinparhttps://www.cell.com/cell/fulltext/S0092-8674(22)00843-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 5, 2022

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