Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editingThe genetic mutation underlying a severe immune system deficiency can be corrected by adenine base editing of human patient stem cells, restoring the ability of these cells to develop into functional T cells in model systems, and paving the path for future treatment of CD3δ SCID in patients.The genetic mutation underlying a severe immune system deficiency can be corrected by adenine base editing of human patient stem cells, restoring the ability of these cells to develop into functional T cells in model systems, and paving the path for future treatment of CD3δ SCID in patients.Grace E. McAuley, Gloria Yiu, Patrick C. Chang, Gregory A. Newby, Beatriz Campo-Fernandez, Sorel T. Fitz-Gibbon, Xiaomeng Wu, Sung-Hae L. Kang, Amber Garibay, Jeffrey Butler, Valentina Christian, Ryan L. Wong, Kelcee A. Everette, Anthony Azzun, Hila Gelfer, Christopher S. Seet, Aru Narendran, Luis Murguia-Favela, Zulema Romero, Nicola Wright, David R. Liu, Gay M. Crooks, Donald B. Kohnhttps://www.cell.com/cell/fulltext/S0092-8674(23)00170-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 23, 2023

Powered by WPeMatico