Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor functionRING-Bait technology hijacks the process of templated aggregation to recruit ubiquitination machinery and selectively degrade pathogenic tau assemblies without generating a specific binder, thereby reducing tau pathology and improving motor function in vivo.RING-Bait technology hijacks the process of templated aggregation to recruit ubiquitination machinery and selectively degrade pathogenic tau assemblies without generating a specific binder, thereby reducing tau pathology and improving motor function in vivo.Lauren V.C. Miller, Guido Papa, Marina Vaysburd, Shi Cheng, Paul W. Sweeney, Annabel Smith, Catarina Franco, Taxiarchis Katsinelos, Melissa Huang, Sophie A.I. Sanford, Jonathan Benn, Jasmine Farnsworth, Katie Higginson, Holly Joyner, William A. McEwan, Leo C. Jameshttps://www.cell.com/cell/fulltext/S0092-8674(24)00912-7?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 14, 2024

Powered by WPeMatico