CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanismsAntigen presentation to T cells is often studied in the context of proteins. Analyses of nearly 2,000 distinct human CD1 antigen complexes demonstrate broad sampling of self-cellular lipids for display to T cells, where each CD1 protein captures lipid ligands that differ in size, stoichiometry, and chemical structure.these general lipid motifs can be compared to lipids that contribute to disease, providing new biomedical insights.Antigen presentation to T cells is often studied in the context of proteins. Analyses of nearly 2,000 distinct human CD1 antigen complexes demonstrate broad sampling of self-cellular lipids for display to T cells, where each CD1 protein captures lipid ligands that differ in size, stoichiometry, and chemical structure.these general lipid motifs can be compared to lipids that contribute to disease, providing new biomedical insights.Shouxiong Huang, Adam Shahine, Tan-Yun Cheng, Yi-Ling Chen, Soo Weei Ng, Gautham R. Balaji, Rachel Farquhar, Stephanie Gras, Clare S. Hardman, John D. Altman, Nabil Tahiri, Adriaan J. Minnaard, Graham S. Ogg, Jacob A. Mayfield, Jamie Rossjohn, D. Branch Moodyhttps://www.cell.com/cell/fulltext/S0092-8674(23)00912-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 19, 2023

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