A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development

By admin In News, Technology, Wireless Cell Telecom No comments

A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for developmentA transient retrotransposon induction in mammalian preimplantation embryos yields numerous gene regulatory events. Deletion of an MT2B2 retrotransposon promoter abolishes a Cdk2ap1 isoform (Cdk2ap1ΔN), impairing cell proliferation and causing embryonic lethality. Cdk2ap1ΔN is evolutionarily conserved, generated by species-specific promoters, including transposon-derived promoters, to yield divergent expression patterns.A transient retrotransposon induction in mammalian preimplantation embryos yields numerous gene regulatory events. Deletion of an MT2B2 retrotransposon promoter abolishes a Cdk2ap1 isoform (Cdk2ap1ΔN), impairing cell proliferation and causing embryonic lethality. Cdk2ap1ΔN is evolutionarily conserved, generated by species-specific promoters, including transposon-derived promoters, to yield divergent expression patterns.Andrew J. Modzelewski, Wanqing Shao, Jingqi Chen, Angus Lee, Xin Qi, Mackenzie Noon, Kristy Tjokro, Gabriele Sales, Anne Biton, Aparna Anand, Terence P. Speed, Zhenyu Xuan, Ting Wang, Davide Risso, Lin Hehttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2901104-1%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 13, 2021

Powered by WPeMatico