Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

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Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccinesA clinical stage multivalent SARS-CoV-2 spike receptor-binding domain nanoparticle vaccine (RBD-NP) is protective in mice after a single immunization and elicits strong antibody responses across circulating mutants and broader sarbecoviruses. Multivalent sarbecovirus RBD-NPs can heterotypic protection as serve as a broad therapeutic against coronaviruses.A clinical stage multivalent SARS-CoV-2 spike receptor-binding domain nanoparticle vaccine (RBD-NP) is protective in mice after a single immunization and elicits strong antibody responses across circulating mutants and broader sarbecoviruses. Multivalent sarbecovirus RBD-NPs can heterotypic protection as serve as a broad therapeutic against coronaviruses.Alexandra C. Walls, Marcos C. Miranda, Alexandra Schäfer, Minh N. Pham, Allison Greaney, Prabhu S. Arunachalam, Mary-Jane Navarro, M. Alejandra Tortorici, Kenneth Rogers, Megan A. O’Connor, Lisa Shirreff, Douglas E. Ferrell, John Bowen, Natalie Brunette, Elizabeth Kepl, Samantha K. Zepeda, Tyler Starr, Ching-Lin Hsieh, Brooke Fiala, Samuel Wrenn, Deleah Pettie, Claire Sydeman, Kaitlin R. Sprouse, Max Johnson, Alyssa Blackstone, Rashmi Ravichandran, Cassandra Ogohara, Lauren Carter, Sasha W. Tilles, Rino Rappuoli, Sarah R. Leist, David R. Martinez, Matthew Clark, Roland Tisch, Derek T. O’Hagan, Robbert Van Der Most, Wesley C. Van Voorhis, Davide Corti, Jason S. McLellan, Harry Kleanthous, Timothy P. Sheahan, Kelly D. Smith, Deborah H. Fuller, Francois Villinger, Jesse Bloom, Bali Pulendran, Ralph Baric, Neil P. King, David Veeslerhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2901062-X%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 15, 2021

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