Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species

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Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across speciesTabebordbar et al. evolved a family of RGD-containing AAV capsid variants in mice and primates that enable highly effective systemic gene delivery to muscles. They show these capsids are dependent on integrin heterodimers for transduction across species and enable achieving therapeutic efficacy after systemic administration at low dose.Tabebordbar et al. evolved a family of RGD-containing AAV capsid variants in mice and primates that enable highly effective systemic gene delivery to muscles. They show these capsids are dependent on integrin heterodimers for transduction across species and enable achieving therapeutic efficacy after systemic administration at low dose.Mohammadsharif Tabebordbar, Kim A. Lagerborg, Alexandra Stanton, Emily M. King, Simon Ye, Liana Tellez, Allison Krunnfusz, Sahar Tavakoli, Jeffrey J. Widrick, Kathleen A. Messemer, Emily C. Troiano, Behzad Moghadaszadeh, Bryan L. Peacker, Krystynne A. Leacock, Naftali Horwitz, Alan H. Beggs, Amy J. Wagers, Pardis C. Sabetihttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2901002-3%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 14, 2021

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