Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader DevelopmentA synthetic chemistry and chemo-proteomics platform used to annotate the “degradable kinome” provides chemical leads for developing degraders of approximately 200 distinct kinase targets and offers new general design principles for developing future kinase degraders.A synthetic chemistry and chemo-proteomics platform used to annotate the “degradable kinome” provides chemical leads for developing degraders of approximately 200 distinct kinase targets and offers new general design principles for developing future kinase degraders.Katherine A. Donovan, Fleur M. Ferguson, Jonathan W. Bushman, Nicholas A. Eleuteri, Debabrata Bhunia, SeongShick Ryu, Li Tan, Kun Shi, Hong Yue, Xiaoxi Liu, Dennis Dobrovolsky, Baishan Jiang, Jinhua Wang, Mingfeng Hao, Inchul You, Mingxing Teng, Yanke Liang, John Hatcher, Zhengnian Li, Theresa D. Manz, Brian Groendyke, Wanyi Hu, Yunju Nam, Sandip Sengupta, Hanna Cho, Injae Shin, Michael P. Agius, Irene M. Ghobrial, Michelle W. Ma, Jianwei Che, Sara J. Buhrlage, Taebo Sim, Nathanael S. Gray, Eric S. Fischerhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931445-8%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 4, 2020

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