Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

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Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serologySerological analyses of 650 SARS-CoV-2-exposed individuals show that 90% of the serum or plasma neutralizing activity targets the virus receptor-binding domain, with structural insights revealing how distinct types of neutralizing antibodies targeting the ACE2-binding site dominate the immune response against SARS-CoV-2 spike.Serological analyses of 650 SARS-CoV-2-exposed individuals show that 90% of the serum or plasma neutralizing activity targets the virus receptor-binding domain, with structural insights revealing how distinct types of neutralizing antibodies targeting the ACE2-binding site dominate the immune response against SARS-CoV-2 spike.Luca Piccoli, Young-Jun Park, M. Alejandra Tortorici, Nadine Czudnochowski, Alexandra C. Walls, Martina Beltramello, Chiara Silacci-Fregni, Dora Pinto, Laura E. Rosen, John E. Bowen, Oliver J. Acton, Stefano Jaconi, Barbara Guarino, Andrea Minola, Fabrizia Zatta, Nicole Sprugasci, Jessica Bassi, Alessia Peter, Anna De Marco, Jay C. Nix, Federico Mele, Sandra Jovic, Blanca Fernandez Rodriguez, Sneha V. Gupta, Feng Jin, Giovanni Piumatti, Giorgia Lo Presti, Alessandra Franzetti Pellanda, Maira Biggiogero, Maciej Tarkowski, Matteo S. Pizzuto, Elisabetta Cameroni, Colin Havenar-Daughton, Megan Smithey, David Hong, Valentino Lepori, Emiliano Albanese, Alessandro Ceschi, Enos Bernasconi, Luigia Elzi, Paolo Ferrari, Christian Garzoni, Agostino Riva, Gyorgy Snell, Federica Sallusto, Katja Fink, Herbert W. Virgin, Antonio Lanzavecchia, Davide Corti, David Veeslerhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931234-4%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 17, 2020

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