Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy

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Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategyDu et al. show how a potent COVID-19 antibody, BD-368-2, interacts with the SARS-CoV-2 Spike trimer to neutralize the virus and effectively treat severely infected hamsters. They further demonstrate how BD-368-2 can be paired with additional antibodies to form a cocktail that prevents the evolution of viral escape mutants.Du et al. show how a potent COVID-19 antibody, BD-368-2, interacts with the SARS-CoV-2 Spike trimer to neutralize the virus and effectively treat severely infected hamsters. They further demonstrate how BD-368-2 can be paired with additional antibodies to form a cocktail that prevents the evolution of viral escape mutants.Shuo Du, Yunlong Cao, Qinyu Zhu, Pin Yu, Feifei Qi, Guopeng Wang, Xiaoxia Du, Linlin Bao, Wei Deng, Hua Zhu, Jiangning Liu, Jianhui Nie, Yinghui Zheng, Haoyu Liang, Ruixue Liu, Shuran Gong, Hua Xu, Ayijiang Yisimayi, Qi Lv, Bo Wang, Runsheng He, Yunlin Han, Wenjie Zhao, Yali Bai, Yajin Qu, Xiang Gao, Chenggong Ji, Qisheng Wang, Ning Gao, Weijin Huang, Youchun Wang, X. Sunney Xie, Xiao-dong Su, Junyu Xiao, Chuan Qinhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931232-0%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 15, 2020

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