Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

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Ribosome Collisions Trigger General Stress Responses to Regulate Cell FateCellular stress, such as amino acid starvation and UV irradiation, causes widespread ribosome collisions. Colliding ribosomes serve as a platform that recruits ZAK⍺ and triggers two inter-related but distinct signaling pathways—the ribotoxic stress response and the integrated stress response—to regulate cell fate decisions.Cellular stress, such as amino acid starvation and UV irradiation, causes widespread ribosome collisions. Colliding ribosomes serve as a platform that recruits ZAK⍺ and triggers two inter-related but distinct signaling pathways—the ribotoxic stress response and the integrated stress response—to regulate cell fate decisions.Colin Chih-Chien Wu, Amy Peterson, Boris Zinshteyn, Sergi Regot, Rachel Greenhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930693-0%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 1, 2020

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