A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

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A Bacterial Effector Mimics a Host HSP90 Client to Undermine ImmunityA bacterial effector operates through a “betrayal-like” mechanism by masquerading as an HSP90 client as a means to achieve specificity for its target. This minimal kinase then phosphorylates a critical active site residue to inactivate an essential chaperone required for host innate immunity.A bacterial effector operates through a “betrayal-like” mechanism by masquerading as an HSP90 client as a means to achieve specificity for its target. This minimal kinase then phosphorylates a critical active site residue to inactivate an essential chaperone required for host innate immunity.Victor A. Lopez, Brenden C. Park, Dominika Nowak, Anju Sreelatha, Patrycja Zembek, Jessie Fernandez, Kelly A. Servage, Marcin Gradowski, Jacek Hennig, Diana R. Tomchick, Krzysztof Pawłowski, Magdalena Krzymowska, Vincent S. Tagliabraccihttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2819%2930908-0%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 13, 2019

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