DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV

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DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHVResolution of KSHV’s asymmetric icosahedral structure is achieved via symmetry-relaxed cryo-EM using sequential localized classification. Interactions between the DNA-translocating portal protein, associated capsid and tegument proteins, and the viral genome reveal surprising variability in tegument protein occupancy and orientation plasticity.Resolution of KSHV’s asymmetric icosahedral structure is achieved via symmetry-relaxed cryo-EM using sequential localized classification. Interactions between the DNA-translocating portal protein, associated capsid and tegument proteins, and the viral genome reveal surprising variability in tegument protein occupancy and orientation plasticity.Danyang Gong, Xinghong Dai, Jonathan Jih, Yun-Tao Liu, Guo-Qiang Bi, Ren Sun, Z. Hong Zhouhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2819%2930834-7%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 23, 2019

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