Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

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Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after ChemotherapyThe proliferation-senescence cell-fate decision after drug treatment is determined by three distinct patterns of p21 dynamics. Either a delayed or acute drug-induced p21 response leads to a senescence fate, while an intermediate pulse of p21 response leads to a proliferation fate. This relation between p21 dynamics and cell fate creates a p21 “Goldilocks zone” that favors cell proliferation after drug treatment.The proliferation-senescence cell-fate decision after drug treatment is determined by three distinct patterns of p21 dynamics. Either a delayed or acute drug-induced p21 response leads to a senescence fate, while an intermediate pulse of p21 response leads to a proliferation fate. This relation between p21 dynamics and cell fate creates a p21 “Goldilocks zone” that favors cell proliferation after drug treatment.Chien-Hsiang Hsu, Steven J. Altschuler, Lani F. Wuhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2819%2930612-9%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJune 14, 2019

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